Research Pathways

Immune System Modification utilizes drugs or stem cell therapy to stop the body’s immune system from attacking insulin-producing beta cells.

Encapsulation involves the development of a device to protect cells from the body's immune response.

Beta Cell Regeneration involves regenerating residual beta cell mass that persists in the body even after many years of living with T1D.

Gene Editing Cell Therapy involves editing cells using gene therapy so that they are not recognized by the T1D autoimmune attack.

Cell Transplantation involves implanting islet cells, stem cells, or precursor cells into a person with type 1 diabetes to achieve insulin independence.

Glucose-Responsive Insulin (GRI), also known as “smart insulin,” is chemically activated in response to changes in blood glucose.

The Advanced Artificial Pancreas is a device that fully mimics the glucose-regulating functions of a healthy pancreas, automatically controlling blood glucose levels by administering the proper balance of hormones.